Top 10 Best Methyl B12 Folate

FEEL BETTER, NATURALLY Our sublingual organic Vitamin B12 folate works together for natural energy, mood, and memory boost - they supports healthy metabolism, immunity and nervous system functioning as well as red blood cell production and iron function. Achieve your fitness goals, perform better at workschool, and improve your overall health and feeling of well-being.. HEART, DIGESTION, BRAIN, PREGNANCY these two vitamins maintain healthy homocysteine levels, heart and brain health, metabolism and GI tract health. Folate is an especially important factor in healthy spinal cord development and consumption is important for women of child-bearing age.. HIGHEST POTENCY While many B12folate supplements contain 1000mcg or less B12 per serving, we give you the same number of servings per bottle at 2000mcg B12 and 800 mcg folate for a healthy ratio.. EASY FOR YOUR BODY TO USE Features methylcobalamin and folinic acid, the bioavailable forms of B12 and folate that are more readily absorbed by the body. Contains no toxic cyanide or synthetic folic acid like other, inferior vitamin supplements. GRADUATED DROPPER FOR EASY DOSING The graduatedprinted dropper allows you to quickly easily measure 2000mcg B12 800mcg folate or another amount thats right for you. No more guessing or counting drops Save time in the morning, and always get an accurate serving size.

METHYL FOLATE 1,000MCG VS FOLIC ACID 1,000MCG - Recent research suggests that l methylfolate is a more active form of folate when compared to folic acid. Folic acid is the synthetic form of Folate. METABOLICALLY ACTIVE 5-MTHF OPTIMZED FOLATE - L Methyl Folate is the biological and active form of folate. It is more immediately absorbed into the bloodstream and requires little processing by the body. METHYLFOLATE vs METHYL B12 - Methyl folate and Methyl B12 are both metabolically active forms of B Vitamins and are far more bioavailable when compared to their non-methylated counterparts. VEGAN SAFE, Manufactured in the USA from Globally Sourced Ingredients, NON-GMO, GLUTEN FREE - Double Wood's L Methylfolate capsules are vegan safe, Manufactured in the USA from Globally Sourced Ingredients, Gluten Free, and Non-GMO. SATIFSACTION ASSURED - If you aren't happy with the product for any reason please contact us and we promise to make things right.

Energizing Cofactors - This formula can help support the cardiovascular and cognitive functioning critical to a balanced mood. It uses Magnesium Citrate, Vitamin B6 Vitamin B12 as methylcobalamin to support optimal synthesis of L-Methylfolate, and subsequent methylation reactions.. Healthy Neurotransmitters - Folate is essential for neurotransmitter health, which impacts concentration, sleep, hormones, mood stability, and overall energy support. Promotes heart health by supporting already healthy homocysteine levels and nitric oxide production.. Key B Vitamins - The body uses the B-12 Vitamin to convert homocysteine into methionine, and Vitamin B6 to turn homocysteine into cysteine. These essential amino acids help regulate metabolic processes and antioxidant activity, which aid in immune support.. Balance Calm - Magnesium is included for a full-range mood support supplement. It helps the COMT enzyme break down dopamine, epinephrine, and norepinephrine - all neurotransmitters that can increase feelings of stress when unbalanced.. No Filler Methylfolate Supplement - MethylPro never uses fillers or excipients like bulking agents, glues, or binders. Non-GMO, soy, gluten, dairy, eggs, and nut-free folate capsules. Take only as directed by a Physician..

Full-Spectrum Vitamin B12 - Plus Methyl Folate Cofactor Methylcobalamin, Adenosylcobalamin Hydroxocobalamin are the 3 most beneficial forms of Vitamin B12, with each having differing functions in the body. They are naturally occurring, biologically active, coenzyme forms of vitamin B12 they are the forms the body needs for cellular utilization. The formula also provides a full serving of L-Methylfolate which is an essential cofactor of B12.. Maximum Strength Maximum Absorption Each serving contains a maximum strength dose of 1000 mcg of B12. The liquid sublingual form also bypasses liver processing and is immediately absorbed into the blood stream.. Methylcobalamin B12 - The Essential Form This is the form needed to raise overall b12 status levels across the body. It is the most prevalent form within the bloodstream and is needed for carrying out the essential functions of vitamin B12.. Adenosylcobalamin B12 The Cellular Energy Form This is the form especially needed by the energy factories of the cells, the mitochondria. Adenosylcobalamin helps mitochondria burn food more efficiently for better energy production and metabolism.. Hydroxocobalamin B12 The Storage Form Shown to be stored and stay in the bloodstream longer and be universally distributed through the body to ensure long lasting B12 levels. Also plays a role in detoxification processes within the body..

Full-Spectrum Vitamin B12 - Plus Methyl Folate Cofactor Methylcobalamin, Adenosylcobalamin Hydroxocobalamin are the 3 most beneficial forms of Vitamin B12, with each having differing functions in the body. They are naturally occurring, biologically active, coenzyme forms of vitamin B12 they are the forms the body needs for cellular utilization. The formula also provides a full serving of L-Methylfolate which is an essential cofactor of B12.. Maximum Strength Maximum Absorption Each serving contains a maximum strength dose of 5000 mcg of B12. The liquid sublingual form also bypasses liver processing and is immediately absorbed into the blood stream.. Methylcobalamin B12 - The Essential Form This is the form needed to raise overall b12 status levels across the body. It is the most prevalent form within the bloodstream and is needed for carrying out the essential functions of vitamin B12.. Adenosylcobalamin B12 The Cellular Energy Form This is the form especially needed by the energy factories of the cells, the mitochondria. Adenosylcobalamin helps mitochondria burn food more efficiently for better energy production and metabolism.. Hydroxocobalamin B12 The Storage Form Shown to be stored and stay in the bloodstream longer and be universally distributed through the body to ensure long lasting B12 levels. Also plays a role in detoxification processes within the body..

Full-Spectrum Vitamin B12 - Plus Methyl Folate Cofactor Methylcobalamin, Adenosylcobalamin Hydroxocobalamin are the 3 most beneficial forms of Vitamin B12, with each having different functions in the body. They are naturally occurring, biologically active, coenzyme forms of vitamin B12, the forms the body needs for cellular utilization. The formula also provides a full serving of L-Methylfolate, an essential cofactor of B12.. Maximum Strength 5000 mcg of B12 Each serving contains a maximum strength dose of 5000 mcg of B12. It also delivers 1000 mcg of Methylfolate per serving.. Methylcobalamin B12 - The Essential Form Methyl B12 is the form needed to raise overall b12 status levels across the body. It is the most prevalent form within the bloodstream and is needed for carrying out the essential functions of vitamin B12.. Adenosylcobalamin B12 The Cellular Energy Form This is the form especially needed by the energy factories of the cells, the mitochondria. Adenosylcobalamin helps mitochondria burn food more efficiently for better energy production and metabolism.. Hydroxocobalamin B12 The Storage Form Shown to be stored and stays in the bloodstream longer and is universally distributed through the body to ensure long-lasting B12 levels. It also plays a role in detoxification processes within the body..

PROFESSIONAL STRENGTH Provides clinically validated dosage of 15mg L Methyl folate in the 5-MTHF calcium salt form. This is the most active form of Folate.. ESSENTIAL METHYL B12 COFACTOR Methylcobalamin B12 and Methylfolate have co-dependent relationships. Both are crucial in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.. ACTIVE FORM OF FOLATE Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid vitamin B9. It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is crucial for those with methylation issues that cannot properly process folic acid.. BRAIN, MOOD ENERGY SUPPORT Essential to neurotransmitters production involved in concentration, sleep, energy, hormones mood.. CARDIOVASCULAR, NITRIC OXIDE NERVE SUPPORT Supports heart health and nerve function by supporting healthy homocysteine levels and nitric oxide production..

Micro Ingredients offers fast-dissolving smooth strawberry-flavored chewable vitamin B12 5000mcg tablets. Chewable tablets provide the most efficient digestion and absorption process to maximize the overall nutrient uptake.. Each pouch offers max strength 240 keto and vegan-friendly tablets that do not require swallowing. A two-a-day vitamin sugar-free formula that contains a 4-month supply of vegan B-12. This super B vitamin supplement offers one of the most important B vitamins in its biologically active free form known as methylcobalamin. An essential micronutrient that is required for sustaining life.. You can enjoy benefits that help convert food into fuel for the body while supporting digestive properties, energy production, and nervous system health. Overall, a convenient way for anyone who suffers from troubled swallowing to still get in their vitamin B12 needs.. Premium non-GMO vitamin B12 supplement. Made without soy, dairy, gluten, preservatives, colors, and tree nuts. Ingredients must pass our 3rd party lab tests to ensure a product that is safe, pure, and potent..

Are you looking for healthy methylation support With diverse normal genetic variations, using active forms of essential vitamins may help maintain healthy methylation, which is crucial to many body processes.. Our unique formula contains vitamin B2, vitamin B6 in its active form pyridoxal 5'-phosphate P5P, vitamin B12 in its active form methylcobalamin, and folate in its active form calcium-L- methyl folate, in addition to creatine monohydrate for supporting energy metabolism and betaine anhydrous sometimes known as trimethylglycine for further methylation support.. Feel the Difference - Take two capsules once or twice daily or as directed by your physician.. The Business Of Giving Back - A majority of NutraMedix profits are donated to charitable organizations.. Over 20 Years Of Nutraceutical Innovation - Founded in 1993, NutraMedix supplies highly bioavailable nutritional supplements to health care professionals and consumers. A majority of NutraMedix profits are donated to charitable organizations..

Methylation Support for Undermethylators - A thoughtful blend of four key B vitamins methylated b12, vitamin B6, riboflavin and folate supplement and TMG trimethylglycine designed to keep the wheels of the methylation cycle turning.. Support Detox, Energy NAD Production - NAD and methylation cycles are closely interconnected. Pairing Methyl Charge b vitamins with your NAD supplements supports optimal synergy. The methylation cycle affects glutathione production, detoxification, and processes related to aging, and may act as a supportive energy supplement.. Fast-Acting Absorption Technology - Vitamin B supplements delivered to the body with state-of-the-art liposomal delivery. Liquid b12, riboflavin folate supplement designed to offer complete uptake through the cells of the mouth for results you can feel.. The Difference Is Clear - This products clear consistency can only be achieved with liposomes that are small enough to pass between cells. The smaller, more stable vesicles begin absorbing as soon as they hit the mouth. Each ml delivers powerful b complex vitamins 4 in total and TMG with 50 servings per bottle.. Vegan, Non-GMO Tested Gluten Free - This vitamin b supplement is tested free of Gluten, Soy Protein, and other major allergens. The phospholipids are from purified sunflower lecithin. May be an ideal upgrade to a standard vegan b12 liquid..

Optimize B12 Levels with Synergistic Nutrients - There are many conditions where a B12 deficiency acts as an etiological or aggravating factor. Many of these have been shown to improve with adequate B12 supplementation very high doses of 0.5-1 mg. It is often necessary to optimize the status of many other synergistic nutrients to support the reversal of these conditions. . Synergistic B12 Combo - Trifolamin lozenges provide a synergistic combination of the three bioavailable forms of vitamin B12, as methylcobalamin, hydroxycobalamin, and adenosylcobalamin, with the naturally active form of folate as 6s-5-methyltetrahydrofolate. These three forms of B12 are naturally present in foods and can be readily converted in the body to the active intracellular forms of B12. . Lozenge Delivery System - Trifolamin's lozenge delivery system allows for optimal absorption of B12 and folate. It is best to take Trifolamin after a meal and to allow the lozenge to dissolve slowly and completely in the mouth before swallowing. . Higher Standards. Better Results - Designs for Health maintains a strict, no-compromises approach to quality raw material selection. We never cut corners with substandard ingredients.. Clinically-Trusted Care - DFH is the 1 practitioner supplement brand recommended by functional medicine professionals and the 1 practitioner supplement brand personally trusted by functional medicine professionals..

A unique formula that combines bioactive forms of four essential B vitamins with trimethylglycine betaine.. Vitamins B2, B6, B12, and folate are provided in active, coenzyme forms for maximal bioavailability and function.. These ingredients work together to synergistically support methylation processes and help maintain normal homocysteine metabolism.. Hypoallergenic product free of the following common allergens milkcasein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soybeans, and corn. Contains no artificial colors, flavors, or preservatives.. Trusted by healthcare practitioners since 1969, Klaire Labs products are developed closely with physicians and are intended to be used as directed by a healthcare practitioner..

Just One Drop - Super Liquid Folate contains 400 mcg of folinic acid, along with 40 mcg of vitamin B12 as methylcobalamin per one drop serving.. Folate B12 Teamwork - Research suggests that folate is an important nutrient for maintaining healthy homocysteine levels. Vitamin B12 is present in case of unknown need for this important nutrient.. Easy To Use - The liquid form allows for easy titration and rapid absorption. . Higher Standards. Better Results - Designs for Health maintains a strict, no-compromises approach to quality raw material selection. We never cut corners with substandard ingredients. This product is Non-GMO, Gluten-Free, and Vegetarian-friendly.. Clinically-Trusted Care - DFH is the 1 practitioner supplement brand recommended by functional medicine professionals and the 1 practitioner supplement brand personally trusted by functional medicine professionals..

Fast Acting B Vitamin Boost - Reach for this B complex liquid when you need a quick edge. The highly bioavailable liposomal form includes bioactive forms like methylated b12 and offers more immediate effects over non-liposomal b vitamins. Go Liposomal for Unsurpassed Absorption - Age, genetic variation, medications, and low stomach acid can inhibit Vitamin B and B12 supplement absorption. This vit B complex begins absorbing as soon as it hits the tongue and circulates quickly in the body to bypass common digestive barriers. Premium Nutrient Forms - Includes biotin, folate, methyl B12 methylcobalamin, vitamin B6, riboflavin, pantothenic acid, niacin and a thiamin B1 supplement. These forms are easily recognized by the body, which may better support energy, cognitive function, and methylation. TMG Milk Thistle - To further support the actions of this methylated b complex, TMG plays a vital role in methylation. Milk thistle supports the livers detoxification pathways. Each bottle contains 50 servings of liquid vitamins for women and men. The Difference Is Clear - The clear consistency of this vitamin b complex can only be achieved with liposomes that are small enough to pass between cells. The smaller, more stable vesicles begin absorbing as soon as they hit the mouth. Each bottle contains 50 servings of b complex vitamins.

A comprehensive b vitamins and trimethylglycine supplement designed to support optimal methylation and help maintain healthy homocysteine levels already within normal range.. Features five key nutrients that are involved in homocysteine metabolism folate as calcium folinate and Quatrefolic for increased bioactivity betaine anhydrous trimethylglycine and B6, B2, and B12 vitamins.. The b complex nutrients in this formula are provided in activated forms methylated B12, methylated folate, pyridoxal 5 phosphate, riboflavin 5 phosphate to support enhanced methylation and overall cardiovascular health.. Can act as a supportive cardiovascular supplement. Premotes neurological health and healthy methylation of estrogen, dopamine, epinephrine, and environmental toxins. Formulated to Exclude Wheat, gluten, corn, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms GMOs, artificial colors, artificial sweeteners, and artificial preservatives. B12 Folate supplement for women and men..

POWERFUL METHYL FOLATE COMPLEX Unlike other standalone Methyl Folate Supplements, we included pyridoxal 5-phosphate P-5-P, the coenzyme form of Vitamin B6 and methylcobalamin, a highly bioavailable form of Vitamin B12 to ensure you receive a comprehensive formula to support your health.. SUPPORTS MANY FUNCTIONS Methyl Folate with B12 and B6 helps support mood, energy, immune system and brain health. Just one capsule provides you with 400 mcg of bioavailable patented Methyl Folate, 500 mcg of methylated Vitamin B12 and 8 mg of Vitamin B6.. WITH VITAMIN B12 AND B6 There are many methyl folate supplements available, but most do not include critically important Vitamin B12 and B6. Our Methyl Folate Supplement includes Vitamin B12 as methylcobalamin and Vitamin B6 as pyridoxal 5-phosphate, which are bioavailable forms of these vitamins to help maximize the benefits.. METABOLICALLY ACTIVE FOLATE Methylfolate is the biologically active, naturally occurring form of folate that has shown superior bioavailability. We use the Active folate L-5-MTHF, which is the Calcium Salt L-5-Methyltetrahydrofolate, a highly bioavailable form of folate with excellent stability.. COMMITMENT TO QUALITY Sunergetics Methylfolate plus Vitamin B6 and Vitamin B12 is manufactured in an NSF Certified Facility that adheres to Good Manufacturing Practices GMP..

High-potency, fast-dissolving tablets featuring bioactive forms of both vitamin B12 1000mcg methylcobalamin and folate to support cardiovascular and nervous system health.. Convenient lozenge form supports optimal absorption and utilization by the body.. Folate complements actions of B12 for homocysteine methylation and nervous system function. These tiny tablets use premium active folate methylfolate.. Hypoallergenic product free of the following common allergens milkcasein, eggs, fish, shellfish, tree nuts, peanuts, wheat, and soybeans. Contains no artificial colors, flavors, or preservatives.. Trusted by healthcare practitioners since 1969, Klaire Labs products are developed closely with physicians and are intended to be used as directed by a healthcare practitioner..

POWERFUL TEAMWORK - Folate B12 work synergistically, promoting methylation and helping to promote balanced concentrations of homocysteine. Ideal for vegans and vegetarians.. SUPERIOR FOLATE - This proprietary NatureFolate blend contains safe, naturally-occurring folates in their active 5-MTHF form.. ACTIVE FORMS OF B12 - The premium B12 in this product comes from equal amounts of adenosylcobalamin and methylcobalamin. With 2000 mg per capsule.. HIGHER STANDARDS. BETTER RESULTS - Designs for Health maintains a strict, no-compromises approach to quality raw material selection. We never cut corners with substandard ingredients. This product is Non-GMO, Gluten-Free, and Vegetarian-friendly.. OVER 50,000 DOCTORS AGREE - Designs for Health is the physician's choice for top quality professional strength supplements since 1989. Our Science First philosophy ensures our products are based on the most recent research and use the highest quality raw ingredients..

1 In Professional Strength Methylfolate - MethylPro is the leading nutraceutical line featuring l-methylfolate, the most active, advanced form of folate. Whereas many methylfolate products contain mcg or 1mg amounts, our products provide a range of therapeutic dosing options.. Doctor Developed B Complex - Eliminate the need for extra B-vitamin supplements. Doctors most familiar with L-Methylfolate have developed this comprehensive and convenient B-Complex.. 100X More Soluble - Feel the difference of the most advanced methylfolate on the market. Quatrefolic, the 4th generation folate, is 100x more water soluble than calcium salt derivative, a common form of methylfolate.. Brain Cardiovascular Support - L-Methylfolate is important for the production of neurotransmitters involved in concentration, sleep, hormones, mood stability and energy. May help promote heart health by supporting already healthy homocysteine levels and nitric oxide production.. No Fillers - MethylPro never uses fillers or excipients like bulking agents, glues, or binders. This product is free of gluten, dairy, eggs, and nuts. Take only as directed under the supervision of a Physician..

Bioactive B Vitamins Methyl B-12 and Methyl Folate provides methylcobalamin methyl B-12 and methyl folate, which are the biologically active forms of vitamin B12 and B9, plus pyridoxal-5-phosphate P5P, the coenzyme form of vitamin B6. Full-Body Benefits This Jarrow Formulas supplement combines the active forms of these vitamins to support energy production, brain function, DNA and neurotransmitter synthesis, and amino acid metabolism. Homocysteine Metabolism Methyl B-12 and methyl folate facilitate the metabolism of homocysteine into methionine, while P5P facilitates the metabolism to cysteine. Convenient Chewable Tablet Each lemon-flavored chewable tablet delivers 1.5 mg of vitamin B6, 680 mcg of folate, and 1000 mcg of vitamin B12 Our formula contains no wheat, gluten, soybeans, dairy, egg, fish, shellfish, or peanuts and tree nuts. Superior Nutrition and Formulation The goal of Jarrow Formulas is to promote optimal health with high-quality, effective, affordable, and superior formulation of dietary supplements Our customers can be assured of purity, value, and potency.

Bioactive B Vitamins Methyl B-12 and Methyl Folate provides methylcobalamin methyl B-12 and methyl folate, which are the biologically active forms of vitamin B12 and B9, plus pyridoxal-5-phosphate P5P, the coenzyme form of vitamin B6. Full-Body Benefits This Jarrow Formulas supplement combines the active forms of these vitamins to support energy production, brain function, DNA and neurotransmitter synthesis, and amino acid metabolism. Homocysteine Metabolism Methyl B-12 and methyl folate facilitate the metabolism of homocysteine into methionine, while P5P facilitates the metabolism to cysteine. Convenient Chewable Tablet Each cherry-flavored chewable tablet delivers 2.5 mg of vitamin B6, 1360 mcg of folate, and 5000 mcg of vitamin B12 Our formula contains no wheat, gluten, soybeans, dairy, egg, fish, shellfish, or peanuts and tree nuts. Superior Nutrition and Formulation The goal of Jarrow Formulas is to promote optimal health with high-quality, effective, affordable, and superior formulation of dietary supplements Our customers can be assured of purity, value, and potency.

Lab tested and most powerful Methylfolate supplying essential support for DNA and neurotransmitter synthesis along with amino acid metabolism.. Developed as most optimally absorbed and bioavailable 5-MTHF. Delivering key supplementation for brain, heart and nerve function, as well as support for women who are pregnant and overall health. Suitable for people who are diagnosed with MTHFR mutation. To ensure purity and safety, our products are manufactured in a fully GMP-certified facility. Our product is third party tested to assure the quality and purity of each batch. All Made in USA..

GI Health Vitamin B12 Folate work together to support the health of the gastrointestinal tract. Nerve Support Formula Methylated forms of B12 folate are considered to be the most bioavailable. Prenatal Vitamins Folate as L-5-MTHF 800mcg may reduce the risk of neural tube birth defects. Quality, Purity Potency No coatings or binders, gluten-free, dairy-free, soy-free sugar-free. Vital Nutrients Committed to making high-quality supplements that support health vitality.

Activated B Vitamins PureMelt B12 Folate contains a combination of activated vitamin B12, as methylcobalamin, and Metafolin 5-methyltetrahydrofolate L-5-MTHF, the naturally occurring, universally metabolized form of folate.. Great Taste Great tasting, fruit flavored lozenge uniquely designed to dissolve in the mouth without requiring water.. Cellular Health Activated B vitamins provide methyl groups to support healthy methylation, a key regulator of genetic expression and cellular function.. Pure Quality Our supplements are made with only premium ingredients sourced from trusted suppliers and guided by our nutritional experts, then carefully manufactured and tested to verify their potency and purity.. Pure Difference What makes us different isn't just our process or what goes into our supplements -- what we leave out matters, too. Pure Encapsulations products are FREE FROM wheat, eggs, tree nuts peanuts, gluten, artificial colors, flavors sweeteners, coatings and shellacs, GMOs, and unnecessary binders, fillers preservatives..

Energy Support As coenzymes, the B vitamins play an important role in proper energy production, including the metabolism of lipids, carbohydrates, and proteins.. Unique B Vitamins Methylfolate and methylcobalamin are the predominant forms of B vitamins commonly found in cells that do not require additional conversion in the body.. VitaminsMineralsAmino Acids Our vitaminsminerals and amino acid formulas are developed to provide beneficial support in filling nutrient gaps.. Our uncompromising operational practices at our state-of-the-art manufacturing facilities surpass GMP standards and manufacturing regulations. All of our products are GMO-free.. For 65 years, Douglas Laboratories has been dedicated to meeting the needs of healthcare professionals. As a globally recognized leader in the development of innovative, science-based nutritional supplements, we strive to help healthcare professionals and their patients push their potential to live healthier, today and in the future..

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ESSENTIAL FOR ENERGY PRODUCTION Vitamin B-12 is necessary for the production of energy from fats and proteins and is well known for its critical role in DNA synthesis, as well as in homocysteine metabolism.. METHYLCOBALAMIN PLUS FOLIC ACID Methyl B-12 is vegetarianvegan non-animal derived.. CERTIFICATIONSCLASSIFICATIONS Kosher, Soy Free, Vegan. GMP Quality Assured NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratorytesting methods for stability, potency, and product formulation.. Packaged in the USA by a family owned and operated company since 1968.. During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided..